欢迎来到2019英雄联盟S9外围公共卫生学院!

  • 杨晓波
  • 发表时间: 2017-04-26
  • 杨晓波,博士、教授、博士生导师,校长办公室主任,兼公共卫生学院副院长。教育部新世纪优秀人才、霍英东青年教师基金、广西首届杰出青年基金、2019英雄联盟S9外围杰出青年人才培养计划入选者。1997.9-2007.7就读于华中科技大学同济医学院公卫学院,2007.10-2008.3在美国UAB大学做博士后研究。现任中国毒理学会神经毒理专委会青年委员、免疫毒理专委会委员,广西预防医学会劳动卫生与职业病专业委员会常委、广西医学会临床流行病学与循证医学分会常委,全国研究生教材《分子毒理学》编委。

    研究方向主要为环境暴露组与基因组学,有丰富的队列设计与研究经验,先后设计并组建了中国防城港男性健康人群队列(1万例),重金属锰暴露人群队列(2800例)、广西多中心出生队列(6200例)。作为项目负责人主持国家自然科学基金项目 3 项、教育部课题 2 项、霍英东青年教师基金项目 1 项、广西首届杰出青年基金 1项等10余项课题。迄今发表SCI 论文 78 篇,影响因子总数 284.21,合计被引次数为630次,他引526次;第一作者或通讯作者SCI论文共 25 篇,影响因子总数为 97.8 IF>57篇, 其中第一/共同第一作者SCI论文9篇,通讯/并列通讯作者论文16篇,总被引用217次,包括发表于Environmental Health Perspectives(最新IF=8.44, PLoS Genetics2012 IF=8.51),Hum Mol Genet2012 IF=7.69),Scientific Reports(IF=5.22)等高影响力SCI杂志。

     

    近年承担的科研项目:

      1.国家自然科学基金:基因遗传变异对锰暴露工人血浆锰和细胞毒作用的遗传调控(项目编号:81472962

      2.国家自然科学基金:PI3K/Akt信号通路及热应激蛋白在MMT燃烧产物致神经毒性中的作用机制(项目编号:21167004

      3.国家自然科学基金:职业锰暴露工人血清多巴胺及神经行为功能影响的遗传机制研究(项目编号:81060234

      4.2012年度教育部新世纪优秀人才资助项目(项目编号:NCET-12-0653Supported by Program for New Century Excellent Talents in University

      5.霍英东青年教师基金:广西重金属锰暴露工人健康队列组建及神经认知功能损伤研究(141118

      6.教育部博士点新教师类基金:环境-遗传交互作用对锰暴露工人血清多巴胺及神经行为功能的调控机制研究(项目编号:20104503120006

      7.广西杰出青年基金项目:基于GWAS发掘的遗传变异探讨环境-遗传交互作用对锰暴露的神经毒性机制(项目编号:2012GXNSFFA060009

      8.广西科技开发项目:广西职业锰暴露人群大样本健康队列的构建及早期健康效应研究(桂科攻1355007-1

      9.广西高校优秀人才资助课题:广西职业锰暴露工人研究队列建立

     

    近年来发表的第一作者和通讯作者SCI收录论文目录:(标注*号为通讯作者)

     

    1.           Xiaobo Yang, Jingping Zheng,Yun Bai,Fengjie Tian,Jing Yuan,Jianya Sun,Huashan Liang,Liang Guo, Hao Tan,Weihong Chen,Robert M. Tanguay,and Tangchun Wu. Using biomarkers of lymphocytes and plasma Hsp70 for assessing coke oven exposure among steel workers. Environmental Health Perspectives, 2007; 115(11):1573-7. (最新IF=8.44).PMID: 18007987

    2.           Yang X, Sun J, Gao Y, Tan A, Zhang H, Hu Y , Feng J,Qin X,Tao S,Chen Z,Kim ST,Peng T,Liao M,Lin X,Zhang Z,Tang M,Li L,Mo L,Liang Z,Shi D,Huang Z,Huang X,Liu M,Liu Q,Zhang S,Trent JM,Zheng SL,Xu J,Mo Z. Genome-wide association study for serum complement C3 and C4 levels in healthy Chinese subjects. PLoS Genetics. 2012, 89):e1002916. (IF=8.52). PMID: 23028341

    3.           Lin X#, Lu D#, Gao Y#, Tao S#, Yang X#, Feng J,Tan A,Zhang H,Hu Y,Qin X, Kim ST, Peng T, Li L, Mo L, Zhang S, Trent JM, Mo Z, Zheng SL, Xu J, Sun J. Genome-Wide Association Study Identifies Novel Loci Associated with Serum Level of Vitamin B12 in Chinese Men. Human Molecular Genetics. 2012, 21(11):2610-7. (IF=7.69 ) (*Co-first authors). PMID: 22367966

    4.           Tan A#, Sun J#, Xia N#, Qin X#, Hu Y#, Zhang S#, Tao S#, Gao Y#, Yang X#, Zhang H#, Kim ST, Peng T, Lin X, Li L, Mo L, Liang Z, Shi D, Huang Z, Huang X, Liu M, Ding Q,Trent JM, Zheng SL, Mo Z, Xu J. A genome-wide association and gene-environment interaction study for serum triglycerides levels in a healthy Chinese male population. Human Molecular Genetics. 2012,217):1658-1666. (IF=7.69 ) (* Co-first authors). PMID: 22171074

    5.           Wen W#,Zheng W#,Okada Y#,Takeuchi F#,Tabara Y#,Hwang JY#, Dorajoo R#, Li H#, Tsai FJ#, Yang X#, He J#,Wu Y#, He M#, Zhang Y, Liang J, Guo X, et al. Meta-analysis of genome-wide association studies in East Asian-ancestry populations identifies four new loci for body mass index. Human Molecular Genetics. 2014;23(20):5492-504. (IF=7.69 ) (* Co-first authors). PMID: 24861553

    6.           He M#, Xu M#, Zhang B#, Liang J#, Chen P#, Lee JY#, Johnson TA#, Li H#, Yang X#, Dai J#, Liang L, Gui L, Qi Q, Huang J, Li Y, Adair LS, Aung T, Cai Q, Cheng CY, Cho MC, Cho YS, Chu M, Cui B, Gao YT, Go MJ, Gu D, Gu W, Guo H, Hao Y, Hong J, Hu Z, Hu Y, Huang J, Hwang JY, Ikram MK, Jin G, Kang DH, Khor CC, Kim BJ, Kim HT, Kubo M, Lee J, Lee J, Lee NR, Li R, Li J, Liu J, Long J, Lu W, Lu X, Miao X, Okada Y, Ong RT, Qiu G, Seielstad M, Sim X, Song H, Takeuchi F, Tanaka T, Taylor PR, Wang L, Wang W, Wang Y, Wu C, Wu Y, Xiang YB, Yamamoto K, Yang H, Liao M, Yokota M, Young T, Zhang X, Kato N, Wang QK, Zheng W, Hu FB, Lin D, Shen H, Teo YY*, Mo Z*, Wong TY*, Lin X*, Mohlke KL*, Ning G*, Tsunoda T*, Han BG*, Shu XO*, Tai ES*, Wu T*, Qi L*. Meta-analysis of genome-wide association studies of adult height in East Asians identifies 17 novel loci.Hum Mol Genet. 2015;24(6):1791-800. (IF=7.69 ) (# Co-first authors).

    7.           Zhenfang Liu, Qin Tang, Jing Wen, Yan Tang, DaMin Huang, Yuzhen Huang, Jinling Xie, Yawen Luo, Min Liang, Chunlei Wu, Zheng Lu, Aihua Tan, Yong Gao, Qiuyan Wang, Yonghua Jiang Ziting Yao, Xinggu Lin, Haiying Zhang, Zengnan Mo, Xiaobo Yang*.Elevated serum complement factors 3 and 4 are strong inflammatory markers of the metabolic syndrome development: a longitudinal cohort study. Sci Rep. 2016 Jan 4; 6:18713. (IF=5.578).

    8.           Su C, Chen K, Zou Y, Shen Y, Xia B, Liang G, Lv Y, Wang F, Huang D, Yang X*. Chronic exposure to manganese sulfate leads to adverse dose-dependent effects on the neurobehavioral ability of rats. Environ Toxicol. 2016 Nov;31(11):1571-1579.

    9.           Yunfeng Zou, Li Qing, Xiaoyun Zeng, Yuefei Shen, Yaoqiu Zhong, Jing Liu, Qin Li, Kangcheng Chen, Yingnan Lv, Damin Huang, Guiqiang Liang, Wei Zhang, Lang Chen, Yiping Yang, Xiaobo Yang*. Cognitive Function and Plasma BDNF Levels among Manganese Exposed Smelters. Occupational and Environmental Medicine. 2014. 71(3): 189-94

    10.       Xia B, Chen K, Lv Y, Huang D, Liu J, Liang G, Zhang L, Wang F, Su C, Zou Y, Yang X*. Increased oxidative stress and plasma Hsp70 levels among gasoline filling station attendants. Toxicol Ind Health.  2017.33(2):171-181.

    11.       Liang G Zhang LMa SLv YQin HHuang XQing LLi QChen KXiong FMa YNong JYang X* Zou Y*. Manganese accumulation in hair and teeth as a biomarker of manganese exposure and neurotoxicity in ratsEnviron Sci Pollut Res Int20162312):12265-71.

    12.       Luo Y, Zhang H, Liao M, Tang Q, Huang Y, Xie J, Tang Y, Tan A, Gao Y, Lu Z, Yao Z, Jiang Y, Lin X, Wu C, Xiaobo Yang*. Mo Z. Sex Hormones Predict the Incidence of Erectile Dysfunction: From a Population-Based Prospective Cohort Study (FAMHES). J Sex Med. 2015 12(5):1165-74.

    13.       Tang Q, Liu Z, Tang Y, Tan A, Gao Y, Lu Z, Wang Q, Chen Y, Wu C, Zhang H, Xiaobo Yang*, Mo Z.High serum ferritin level is an independent risk factor for metabolic syndrome in a Chinese male cohort population. Diabetol Metab Syndr. 2015;7:11.

    14.       Wang F, Zou Y, Shen Y, Zhong Y, Lv Y, Huang D, Chen K, Li Q, Qing L, Xia B, Su C, Ma S, Yang X*. Synergistic Impaired Effect between Smoking and Manganese Dust Exposure on Pulmonary Ventilation Function in Guangxi Manganese-Exposed Workers Healthy Cohort (GXMEWHC). PLoS One. 2015 Feb 9;10(2):e0116558. doi: 10.1371/journal.pone.0116558.

    15.       Liang GQin HZhang LMa SHuang XLv YQing LLi QXiong YHuang YChen KHuang YShen YNong JYang X*, Zou Y*. Effects of chronic manganese exposure on the learning and memory of rats by observing the changes in the hippocampal cAMP signaling pathway. Food Chem Toxicol. 2015 Sep;83:261-7.

    16.       Qi Deng, Jing Liu, Qing Li, Kangcheng Chen, Zhenfang Liu, Yuefei Shen, Piye Niu, Yiping Yang, Yunfeng Zou* and Xiaobo Yang*. Interaction of occupational manganese exposure and alcohol drinking aggravates the increase of liver enzyme concentrations from a cross-sectional study in China. Environmental Health. 2013 Apr 15;12:30. doi: 10.1186/1476-069X-12-30.

    17.       Yingnan Lv, Yunfeng Zou, Jing Liu, Kangcheng Chen, Damin Huang,Yuefei Shen, Yaoqiu Zhong, Zhihao Liu, Bei Jiang, Qin Li, Li Qing,Wei Zhang, Lang Chen, Fenfen Wang, Bing Xia, Li Yang, Xiaobo Yang*. Rationale, design and baseline results of the Guangxi manganese-exposed workers healthy cohort (GXMEWHC) study. BMJ Open. 2014;4:e005070.

    18.       Xiaobo Yang, Abu S Abdullah, Bo Wei, Junjun Jiang, Wei Deng, Bo Qin, Weili Yan, Qianqiu Wang, Chaohui Zhong, Qian Wang, Yuhua Ruan, Yunfeng Zou, Peiyan Xie, Fumei Wei,Na Xu,Hao Liang. Factors influencing Chinese male's willingness to undergo circumcision: a cross-sectional study in western China. PLoS ONE.2012:71:e30198.

    19.       Liao M, Ye F, Zhang B, Huang L, Xiao Q, Qin M, Mo L, Tan A, Gao Y, Lu Z, Wu C, Zhang Y, Zhang H, Qin X, Hu Y, Yang X*, Mo Z*. Genome-wide association study identifies common variants at TNFRSF13B associated with IgG level in a healthy Chinese male population. Genes and Immunity.2012, 136:509-513.

    20.       Yang M, Wu Y, Lu Y, Liu C, Sun J, Liao M, Qin M, Mo L, Gao Y, Lu Z, Wu C, Zhang Y, Zhang H, Qin X, Hu Y, Zhang S, Li J, Dong M, Zheng SL, Xu J, Yang X*, Tan A*, Mo Z*.Genome-Wide Scan Identifies Variant in TNFSF13 Associated with Serum IgM in a Healthy Chinese Male Population. PLoS One. 2012;7(10):e47990.

    21.       Ye F, Liu Z, Tan A, Liao M, Mo Z*, Yang X*. XRCC1 and GSTP1 polymorphisms and prognosis of oxaliplatin-based chemotherapy in colorectal cancer: a meta-analysis. Cancer Chemother Pharmacol. 2013,71(3):733-740.

    22.       Yang X, Yuan J, Sun J, Wang H, Liang H, Bai Y, Guo L, Tan H, Yang M, Wang J, Su J, Chen Y, Tanguay RM, Wu T.Jing Yuan, Jianya Sun. Association between heat-shock protein 70 gene polymorphisms and DNA damage in peripheral blood lymphocytes among coke-oven workers. Mutation Research. 2008; 649(1-2):221-9.

    23.       Liu Z, Ye F, Zhang H, Gao Y, Tan A, Zhang S, Xiao Q, Zhang B, Huang L, Ye B, Qin X, Wu C, Lu Z, Zhang Y, Liao M, Yang X*, Mo Z*. The Association between the Levels of Serum Ferritin and Sex Hormones in a Large Scale of Chinese Male Population. PLoS One. 201311;8(10):e75908.

    24.       Lulu Huang, Zhenfang Liu, Donghong Deng, Aihua Tan, Ming Liao, Zengnan Mo, Xiaobo Yang*. .Anti-epidermal growth factor receptor monoclonal antibody-based therapy for metastatic colorectal cancer: a meta-analysis of the effect of PIK3CA mutations in KRAS wild-type patients. Arch Med Sci.  2014; 10, 1: 1–9.

    25.       Wei Wang,* Xiaobo Yang,* Jianbo Liang, Ming Liao, Haiying Zhang, Xue Qin, Linjian Mo, Wenxin Lv, Zengnan Mo. Cigarette smoking has a positive and independent effect on testosterone levels. Hormones-International Journal of Endocrinology and Metabolism.2013 Oct;12(4):567-77.

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